The ER Hyperstress Theory of Autism and Autoimmunity
The ER Hyperstress Theory of Autism and Autoimmunity James Lyons-Weiler, PhD CEO & President The Institute for Pure and Applied Knowledge Causes : 2015 (Skyhorse) 1,000 studies cited With Forward by Dr. Richard Frye Searchable reference database at http://envgencauses.com
Autism is Not Genetic ASD is a Mixture of Phenotypes Heritability, >2,000,000 estimates (any human traits): 1958-2012 (Polderman et al.) Genetics >850 genes involved in Autism
No individual gene accounts for >1% of ASD 20% of autistics have >> Copy Number Variations (CNVs) de Novo variants more common in sporadic vs. familial cases regulatory genes in early development synaptogenesis throughout life Familial vs. Genetic Risk Every mode of inheritance (dominant, recessive, complex) Pinto >2-3 affected genes > ASD risk Functional Groups by Age -9 mo to 0 years Early (pre-natal) regulatory genes CHD7, CHD8 (neural crest, neurogenesis)
Pinto et al Largest Genetic Studies (Hallmayer, 2011; Sandin, 2014) Did not measure any environmental factors Did not estimate G x E interactions Both concluded around 50% E, 50% G Environment, G x E, and Gene x gene Interactions
Inherited common, Universal environment Gaugler T et al. Most genetic risk for autism resides with common variation. Nat Genet. 2014 Aug;46(8):881-5. doi: 10.1038/ng.3039. Epub 2014 Jul 20. Risk of Environmental Susceptibility is Genetic
Boggess et al. 2016. Mean serumlevel of common organic pollutants is predictive of behavioral severity in children with autism spectrum disorders. Sci Rep. 2016 May 13;6:26185. doi: 10.1038/srep26185 .
Environmental Toxin Liability Sampling Theory Aluminum levels in vaccines are unsafe We need to Risk Factors + Biomarkers Vaccine Safety Screening Valproic acid Pregnancy-related stress thimerosal PON1 CHD7
ADRB2 organophosphates ERAP1 MET particulate air pollution MTHFR CBS COMT
Pre/peri-natal vitamins EtHg -> UPR -> Apoptosis How is this Related to HPV VaccineInduced Autoimmunity? Pubs Each Year 45 # Publications ER Stress/ Unfolded Protein
sympathetic nerve dysfunction.42 A published questionnaire43 of HPV vaccination recipients focusing on a combination of chronic illness including POTS, CRPS, and fibromyalgia found that 93 percent of individuals reporting symptoms related to these conditions were still incapacitated and unable to work or attend school four years after vaccination. Additionally, several studies have linked HPV vaccination to primary ovarian failure resulting in impaired fertility 44 45 46 47. Source: NVIC - https://www.nvic.org/vaccines-and-diseases/hpv/vaccine-injury.aspx 10000 8696 x Human Max AL
per Vaccine Dose @ 2 mo (no units) 1000 906 Genetic susceptibility models 217
100 229 1279 326 109 51 63
17 10 11 5 1 217 9662
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Benne a Sheats : Výzkum organizace práce (1948) - definovali rozličné skupinové role, jimiž se jednotlivci podílejí na činnostech skupiny . Jejich typologie rolí a dovedností byla poměrně složitá a zahrnovala 3 hlavní skupiny .
The mission of the sisters is to work to help and to educate the poor and needy of society. The FCJ sisters live and work in the UK and Ireland and in countries around the world. They run schools and...
Supplier training pack in preparation. NPI framework & training needs resolving before this process can be implemented. Engr support to indentify all CCFs created to date. P Gesanidis. 3/29 audits completed and reviewed per new GQP template. 14 NARs outstanding,...
1. a) What is a map? Answers may vary, but should include the following concepts:. Maps are a flat-surface representation of a part (or all) of Earth's surface. Maps use symbols (including colours) to show features on Earth's surface
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