The ER Hyperstress Theory of Autism and Autoimmunity

The ER Hyperstress Theory of Autism and Autoimmunity

The ER Hyperstress Theory of Autism and Autoimmunity James Lyons-Weiler, PhD CEO & President The Institute for Pure and Applied Knowledge Causes : 2015 (Skyhorse) 1,000 studies cited With Forward by Dr. Richard Frye Searchable reference database at http://envgencauses.com

Autism is Not Genetic ASD is a Mixture of Phenotypes Heritability, >2,000,000 estimates (any human traits): 1958-2012 (Polderman et al.) Genetics >850 genes involved in Autism

No individual gene accounts for >1% of ASD 20% of autistics have >> Copy Number Variations (CNVs) de Novo variants more common in sporadic vs. familial cases regulatory genes in early development synaptogenesis throughout life Familial vs. Genetic Risk Every mode of inheritance (dominant, recessive, complex) Pinto >2-3 affected genes > ASD risk Functional Groups by Age -9 mo to 0 years Early (pre-natal) regulatory genes CHD7, CHD8 (neural crest, neurogenesis)

0- 2years Peri/post-natal brain development Synaptogenesis, PRUNING 2-4 years PRUNING, MYELINATION Lifetime Synaptic proteins Glutamate receptors Serotonin receptors (e.g., SCN1A) Cellular detox proteins (ERAP1) Mitochondrial genes (ROS)

Pinto et al Largest Genetic Studies (Hallmayer, 2011; Sandin, 2014) Did not measure any environmental factors Did not estimate G x E interactions Both concluded around 50% E, 50% G Environment, G x E, and Gene x gene Interactions

Inherited common, Universal environment Gaugler T et al. Most genetic risk for autism resides with common variation. Nat Genet. 2014 Aug;46(8):881-5. doi: 10.1038/ng.3039. Epub 2014 Jul 20. Risk of Environmental Susceptibility is Genetic

Boggess et al. 2016. Mean serumlevel of common organic pollutants is predictive of behavioral severity in children with autism spectrum disorders. Sci Rep. 2016 May 13;6:26185. doi: 10.1038/srep26185 .

Environmental Toxin Liability Sampling Theory Aluminum levels in vaccines are unsafe We need to Risk Factors + Biomarkers Vaccine Safety Screening Valproic acid Pregnancy-related stress thimerosal PON1 CHD7

ADRB2 organophosphates ERAP1 MET particulate air pollution MTHFR CBS COMT

Pre/peri-natal vitamins EtHg -> UPR -> Apoptosis How is this Related to HPV VaccineInduced Autoimmunity? Pubs Each Year 45 # Publications ER Stress/ Unfolded Protein

Response AND Autoimmun* 40 35 30 25 20 15 10 5 0 1985

1990 1995 2000 2005 2010 2015

2020 2025 Conditions attributed to Gardasil-9 anaphylaxis,6 lupus,7 8 erythema multiforme,9 acute disseminated encephalomyelitis,10 11 12 transverse myelitis,13 amyotrophic lateral sclerosis (ALS),14 central nervous system demyelination,15 16 multiple sclerosis,17 including pediatric multiple sclerosis,18 Guillain-Barre Syndrome,19 20 pancreatitis,21 22 inflammatory bowel syndrome,23 brachial plexus neuritis,24 brachial neuritis,25 optic neuritis,26 neuromyelitis optica,27 opsoclonus myoclonus,28 evanescent white dot syndrome,29 30 acute cerebellar ataxia,31 autoimmune hepatitis,32 autoimmune neuromyotonia,33 vasculitis,34 thrombocytopenic purpura,35 immune thrombocytopenic purpura,36 Postural Orthostatic Tachycardia Syndrome (POTS),37 38 39 Complex Regional Pain Syndrome (CRPS), 40 Chronic Fatigue Syndrome (CFS),41 and peripheral

sympathetic nerve dysfunction.42 A published questionnaire43 of HPV vaccination recipients focusing on a combination of chronic illness including POTS, CRPS, and fibromyalgia found that 93 percent of individuals reporting symptoms related to these conditions were still incapacitated and unable to work or attend school four years after vaccination. Additionally, several studies have linked HPV vaccination to primary ovarian failure resulting in impaired fertility 44 45 46 47. Source: NVIC - https://www.nvic.org/vaccines-and-diseases/hpv/vaccine-injury.aspx 10000 8696 x Human Max AL

per Vaccine Dose @ 2 mo (no units) 1000 906 Genetic susceptibility models 217

100 229 1279 326 109 51 63

17 10 11 5 1 217 9662

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