National Institutes of Health National Research Service Award

National Institutes of Health National Research Service Award

National Institutes of Health National Research Service Award Ruth L. Kirschstein Fellowship F30, F31, F32 Workshop November 13, 2014 The Graduate College Ken Vickery Mark Zulauf Jim Slauch Dave Kranz Dan Harris Sharee Robinson

NIH/Kirschstein F30, F31, F32 Pre- and Postdoctoral Fellowships -Nuts and BoltsJames M. Slauch Dept of Microbiology Medical Scholars Program November 13, 2014 What are we talking about? Individual fellowships from the National Institutes of Health Whos eligible? Must be a US citizen or permanent resident (at the time of the award) Predocs: 5 Years

MD/PhDs: 6 years including some Med school after PhD. Postdocs: 3 years Years funded by other NIH training grants are subtracted How to Start Give yourself plenty of time ~6 weeks More if you project involves animals or humans Submission F30 F32 F31 April 8 April 13

August 8 August 13 December 8 Dec 13 Scientific Merit June - July Review Advisory Sept - Oct Council Review Oct - Nov Feb - March

Jan - Feb May - June Earliest Project December Start Date April July Program Announcements Can be confusing F31s

PA-14-147 Individual PhD Fellowships PA-14-148 PhD or MD/ PhD Fellowships for underrepresented minority or disabled students PAR-13-127 NINDS MD/PhD Fellowships F30s PA-14-150 MD/PhD Fellowships F32s PA-14-149 Postdoctoral Fellowships PA-12-261 AHRQ Healthcare research and quality How to Start Read the Program Announcement CAREFULLY Why different PAs? Not all Institutes participate in each PA Institutespecific rules Download the Application Instructions

Individual Fellowship Application Guide SF424 (R&R) Read it carefully you dont need to read it all The PA trumps the general instructions How to Start Other useful documents on the Grad College Web site Power points from today Guidance for Preparing and Submitting NIH Kirschstein Fellowship Applications through prepared by OSPRA NRSA Fellowship Application Checklist prepared by Slauch How to Start

Contact your Grants Administrator in your Dept Talk to your thesis advisor who do they go to when filling out an NIH grant? The Grants Administrator should download the application package and fill out all the detailed stuff Register in the ERA Commons All PIs (thats you) need to interact with the NIH via the Commons Go to the OSPRA website and click on Contact OSPRA Choose Proposal-Submitting from the subject picklist. In the text box say: Please register me as a PI in the ERA Commons

UIN First & Last Name Date of birth Email The Application The application is a fancy PDF file The Application The application is a fancy PDF file

There are lots of directions for each item The Application Some info is entered directly the important stuff is uploaded The Application Some info is entered directly the important stuff is uploaded Do NOT put page numbers on the PDFs you create, but do put titles Note that even boxes that are not yellow may be required Letters of Recommendation

Ask for your letters at least three weeks in advance (a months notice is better). Provide your letter writers with a resume as well as a summary of your research interests. They dont need to see the proposal per se. The LORs are submitted electronically. Follow the instruction in section 5.4 of the Application Guide. You are allowed 3-5 LORs NOT your advisor. You must list the referees BOTH in Item 12 AND in the cover letter. Letters of Recommendation Send an email to each letter writer. Dont forget to attach the reference form.

Thank you for agreeing to write me a letter of recommendation for my NRSA application. The due date for my application is [August 8]. The letter must be submitted via the eRA Commons at: n.jsp Please note that you must create a single PDF file that includes the Fellowship Reference Form that is attached. The additional information you need is: PI Commons User ID: [Your Commons ID] PI Last Name: [Your last name] Funding Opportunity Announcement Number: [The appropriate PA number, eg, PA-14-147] Full instructions are pasted below: Part B. Instructions for Referees: Stipend and Tuition Projection Your grant administrator will provide a projection of tuition and

fees for the next six years. This will differ depending on your graduate program. You will also need to show this table to the Graduate College Fellowship Office. Note that this projection is your best estimate and you are not limited by what you say here. The Univ actually bills the NIH later based on real costs. Choose a Study Section Study Section Description Scientific Review

Officer (SRO) F01-F (20) Brain Disorders and Related Neuroscience VILEN MOVSESYAN F02A-J (20) Behavioral Neuroscience KRISTIN KRAMER F02B-M (20)

Sensory, Motor, and Cognitive Neuroscience YUAN LUO F03A-N (20) Neurodevelopment, Synaptic Plasticity and MARY SCHUELER Neurodegeneration F03B-G (20) Biophysical and Physiological Neuroscience PAEK-GYU LEE

F04-A (20) Chemistry, Biochemistry, Biophysics, and Bioengineering ROSS SHONAT Etc Get Feedback Your advisor! Others: Fellow students, post-docs, committee members After your advisor has signed off on it: Ken Vickery Grad College

Application Sign-Off Several university officials must sign off on your application You must allow sufficient time for each of these entities to act. These individuals are not competent to judge the actual proposal. So although you need a complete application to get signatures, you can continue to make minor edits to the proposal and upload new PDF files into the master PDF UNTIL it is time to send it to OSPRA. The Grants Administrator should fill out a Transmittal Form For fellowship applications, the Grad College Fellowship Office also needs to sign off. This is not explicitly listed on the transmittal form; rather this is an other signature if required. Submit completed application that has been reviewed by the appropriate offices (with help from your Grants Administrator) to OSPRA (at least 48 hours in advance).

Other Important Points This is a training grant. The NIH training record of your thesis advisor matters. Ideally, your advisor is: Tenured NIH Funded Has successful PhDs out in the world doing good If not, fear not Seek out a co-advisor that meets the above criteria Good Luck! CONTENT FOR F30/F31

NRSA APPLICATIONS David Kranz and Dan Harris Department of Biochemistry November 13, 2014 Adapted from Lori Raetzman and Paven Aujla, 2012 CHOOSE AN NIH INSTITUTION MSP website: F30 - PA-11-110 ( Participating Institutes: National Cancer Institute (NCI)

National Heart, Lung, and Blood Institute (NHLBI) National Human Genome Research Institute (NHGRI) National Institute on Aging (NIA) National Institute on Alcohol Abuse and Alcoholism (NIAAA)

National Institute of Allergy and Infectious Diseases (NIAID) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) National Institute on Deafness and Other Communication Disorders (NIDCD)

National Institute on Dental and Craniofacial Research (NIDCR) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institute on Drug Abuse (NIDA) National Institute of Environmental Health Sciences (NIEHS)

National Institute of Mental Health (NIMH) Make sure that project fits the institutions mission Preparing an application is a very significant investment of time by you AND your advisor. Need to be aware of this in determining probability of CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators Research Project Training Plan and Potential Institutional Environment (necessary, but usually less critical as a distinguishing factor)

CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators Research Project Training Plan and Potential Institutional Environment (necessary, but usually less critical as a distinguishing factor) APPLICANT IS EVALUATED BY: Academic credentials: grades, productivity, and quality of undergraduate institution - candidates from same school (i.e. UI) may be at disadvantage Demonstrated scientific accomplishmentpublications, presentations; authorship on peerreviewed paper is useful but not essential

Past funding: e.g. graduate fellowship, or slot on NIH training grant Letters of reference (should try to make sure they are excellent): previous mentors/research advisors; try to obtain from both undergrad and grad APPLICANT BIOSKETCH Standard NIH biosketch format including: Personal statement: research interests, past accomplishments, why you can do the proposed research Education and employment Academic and professional honors Activities and memberships Publications (peer reviewed papers, if possible)

Length: 2-4 pages Dan Fellowship Applicant The Kirschstein National Research Award will provide me the opportunity to master technical training in biochemical research. In addition, during this award, I will take part in career development opportunities (i.e. attending conferences, speaking and poster presentations) to further develop the skills of an independent scientific-researcher. Ultimately, this training will prepare me for my goal of becoming a physician-scientist practicing and conducting research in oncology.

Dan DOCTORAL DISSERTATION AND OTHER RESEARCH EXPERIENCE Outline previous research experience Not just techniques learned but questions hypothesized and answered Summarize meetings attended, published papers Length: Two pages

Dan CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators Research Project Training Plan and Potential Institutional Environment (necessary, but usually less critical as a distinguishing factor) SPONSOR AND CO-SPONSOR CRITERIA Research support available: grants and funding sources to your sponsor/advisor Productivity: publications

Mentoring record: previous and current fellows and trainees If your primary sponsor is not strong in all areas, seek out a co-sponsor. Make sure there is a good research fit. Make it very easy on any co-sponsor (e.g. by drafting any paragraph they need to provide, except for their biosketch). A STRONG, LONG-TIME COLLABORATOR OF YOUR SPONSOR CAN BE HELPFUL Could provide evidence of additional methodology that they are experts in and that you will benefit from They could provide additional mentoring opportunities, e.g. if they are an MD

They could provide evidence of opportunity for additional training in a more clinical setting Need Letter of Support and Biosketch from such collaborator your advisor/sponsor should draft such a letter for them COLLABORATORS Collaborators at clinical institutions Reviewers want to know EXACT details about collaboration Our lab has a long-standing collaboration with Professor Hans Schreiber at the University of Chicago, including a program project grant to optimize T cell therapy in various mouse models. In this subaim, I will work with Prof Schreibers lab to examine both the kinetics of T cell infiltration into tumors,

and the efficacy of treatments (see letter from Prof Schreiber) I will be working in collaboration with members of Dr. Hans Schreibers laboratory at The University of Chicago (see letter from Dr. Schreiber). My plan is travel to University of Chicago to work with a member of the Schreiber lab on experiments done with OT-I TCR/RAG-/- and OT-II TCR/RAG-/-mice, preferably in the summer months. I will also travel to University of Chicago once or twice a year to present my data at their lab meeting. This collaboration will not only provide critical feedback on my project, but will allow me to observe and work at a large academic medical center. Dan SPONSOR and COLLABORATORs BIOSKETCHES Standard NIH biosketch format including: Personal statement: research interests, past research accomplishments (papers, grants),

number of students mentored Professional experience Honors and awards Scientific activities Selected publications (15 max) Research support Length: 3-4 pages SPONSOR and COLLABORATORs BIOSKETCHES Standard NIH biosketch format to change in 2015: The new format will allow up to five pages for the entire biosketch, and researchers will be permitted to

describe up to five of their most significant contributions to science, the influence of their contributions on their scientific field, and any subsequent effects of those contributions on health or technology. The new format also will allow researchers to describe their specific role in those discoveries and to annotate their description with up to four publications. CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators Research Project Training Plan and Potential Institutional Environment (necessary, but

usually less critical as a distinguishing factor) RESEARCH PROJECT Specific Aims page: Disease your research addresses and its impact on human health: prevalence, cost, morbidity What is NOT known: e.g. mechanisms of biological

processes that impact the disease; how to design targeted therapeutic Your research question/hypothesis Brief summary of preliminary data: how it fits into question and what is known Specific Aims: experimental design to test hypothesis Length: One page SPECIFIC AIMS EXAMPLE Specific Aim 1. To develop a high affinity TCR against Survivin/HLA-A2 using directed evolution and affinity maturation. Specific Aim 2. Test high-affinity TCRs in the CAR format for targeting T cells against Mart1, WT1 and Survivin antigens in vivo.

Specific Aim 3. To develop a method for rapid isolation of high-affinity TCRs using a universal scaffold. Dan RESEARCH PROJECT Background and significance What is the major question Relevance to human health What will be accomplished if aims are achieved How will these studies change the field How is this approach innovative

Preliminary studies Detailed explanation of figures and results: how they fit into research question and lead to hypothesis Research approach: expand on aims Overview, rationale and design of each aim Anticipated results, potential pitfalls and alternative approaches Length: Six pages Dan RESEARCH PROJECT

NCI Mission Statement: The National Cancer Institute coordinates the National Cancer Program, which conducts and supports research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer, rehabilitation from cancer, and the continuing care of cancer patients and the families of cancer patients. Research Training Plan: Many studies have shown that infiltration of tumors with T cells correlates with improved prognosis (e.g. ref (2)). Therefore, methods that improve T cell recognition of cancer antigens and infiltration of T cells into tumors will have high therapeutic potential. Dan RESEARCH TRAINING PLAN TIPS

Break up sections with headings -Use bold, italics, underlining to emphasize points Dont fill up all the available space -Leave blank lines between sections if you can A picture is worth a thousand words

Your advisor/sponsor should provide advice and examples of previous grants Dan PROJECT SUMMARY Significance of project and relevance with to human health Brief description of what is known about the question you are addressing

How your proposal will address unknown aspects and connect to human health This is published on a public NIH database Length: 2 paragraphs Dan PROJECT NARRATIVE

Very brief description of question you are addressing What results from your proposal will add to knowledge about particular disease or question Lay person should be able to understand Length: One or two sentences

Dan CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators Research Project Training Plan and Potential Institutional Environment (necessary, but usually less critical as a distinguishing factor) TRAINING PLAN Seminars and courses: taken and planned Mentoring: how often will you meet with your sponsor and collaborators, what you will glean from these meetings Scientific meetings: attended and planned

Department/program info: prestige of faculty/department, seminars available to attend; when will you present in addition to group meetings (e.g. annual departmental presentations)?, student support activities Medical Scholars Program (F30 applicants): history and success of the program; annual symposia; meetings Specific information about sponsors: how their background, facilities and equipment will guide your training Applicant qualification and potential for a research career: each sponsor should write a short letter of recommendation pull together how their training and expertise will guide applicant training Length: Six pages GOALS FOR FELLOWSHIP TRAINING AND CAREER

Define applicant career goals Relate to research proposed How will training plan assist and guide applicant career goals Use specifics: techniques used, unique university or program environment that will foster applicant goals; opportunities for exposure to clinical

mentors? Length: One page Dan ACTIVITES PLANNED UNDER AWARD Can use a timeline to outline which aims will be accomplished during which academic years F30 applicants: can explain percent of time that will be

devoted to research/courses and clinical training throughout the proposal timeline Should include meetings, workshops, seminars Anything that will impact and benefit applicant training and exposure (keep career goals in mind) Length: One page Dan ACTIVITES PLANNED UNDER AWARD Explanation of MSP program (most reviewers familiar

with MSTP programs) Outline exactly when you will take M1 courses and how you will split up your time (make sure it is reasonable) Clinical work during PhD Year First Second Third Fourth Fifth Sixth Research

Course Work Clinical 80% 80% 80% 95% 10% 10% 15% 15% 15% 0% 90%

0% 5% 5% 5% 5% 0% 90% Dan TRAINING POTENTIAL The College of Medicine offers a Clinical Practice Preceptorship (CPP) course, which I have taken previously and will continue to take during my graduate studies. The purpose of this program is to maintain a clinical presence during ones graduate work. Students are paired with local

practicing physicians and get to experience clinical medicine a minimum of four times throughout the year. In the past, I have been paired with a practicing oncologist/hematologist and had the opportunity to observe a variety of patients with diverse malignancies. I intend on continuing to work with this physician throughout my graduate studies. Additionally, there is a student run clinic, HeRMES, which I have volunteered for previously. I plan on continuing my volunteer work with HeRMES to not only gain clinical experience but also to provide basic healthcare needs to those in the local community. Dan CORE REVIEW CRITERIA Major criteria: Fellowship Applicant Sponsors and Collaborators

Research Project Training Plan and Potential Institutional Environment (necessary, but usually less critical as a distinguishing factor) FACILITIES AND OTHER RESOURCES List (in outline form) the facilities available to you during your training Ex: Common lab facilities: list all common equipment including centrifuges, microscopes, data processing equipment Core facilities: histology, sequencing, flow cytometry

Your advisor probably has boiler plate documents for these Length: One page (depends on resources) SELECTION OF SPONSOR AND INSTUITION Prestige and reputation of university and applicants affiliated program How selection of university/program fits into applicant research interest and training plan for future career

How sponsors research program and field of expertise fits exactly your goals Length: One page OTHER CONTENT Resource sharing plan Ex. Any

regents or animals planned to be shared in studies proposed a couple of sentences (get this from your sponsor) Letters of support from collaborators Offer help with a technique or training, need biosketch STUDY SUBJECTS VETEBRATE ANIMALS SECTION (if applicable it is mandatory) Species/strains/ages/sex/number

used Complete description of proposed procedures Justification: choice of animal, animal number (detailed breeding plan for transgenic mice) Description of vet care Procedures to minimize discomfort Methods of euthanasia etc. HUMAN SUBJECTS SECTION RESPONSIBLE CONDUCT OF RESEARCH Training plan for NIH ethics requirement

Ex.: If plan to take or have taken MCB ethics course requirement, outline topics covered and how they were covered (texts read, exercises etc.) List any other possible ethics courses, workshops or ethics discussions or mentorship with sponsors Length: One page

RESPECTIVE CONTRIBUTIONS Delineate applicant role in obtaining preliminary data generated for proposal vs. others Applicant role in preparing grant application Length: One page

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