Current Literature in Glycobiology MED 246 / BIOM

Current Literature in Glycobiology MED 246 / BIOM

Current Literature in Glycobiology MED 246 / BIOM 246 / CMM 246 Fall, Winter, Spring Quarters Fridays, 12:00-1:00 PM Faculty Instructors: Lars Bode, Jeff Esko, Pascal Gagneux, Kamil Godula, Philip Gordts, Ajit Varki http://grtc.ucsd.edu

Current Literature in Glycobiology One credit elective Weekly Forum for discussing current literature in glycobiology research Current = within last 6 months Topics: Glycobiology-related Brown Bag (bring your lunch - optional) Selecting the right paper for you

1. Select a scientifically high quality paper!! Selecting the right paper Article from widely read general or top of the line specialty journal Selecting the right paper for you 1. Select a scientifically high quality paper!! [Inside or outside your area of glycan expertise] 2. Consult with your mentor(s) (your PI, Postdoc adviser, lab

members) The assignment really starts here. 3. Propose your article choices to Philip Gordts: [email protected] 10-14 days prior to presentation 4. Email article + supplementary file to Tracy Gilstrap: [email protected] 7 days prior to presentation (Friday before your presentation) http://grtc.ucsd.edu Current Literature in Glycobiology

40-45 min critical discussion Structured: Introduction Hypothesis Specific Aims General Method(s) (if applicable) Results Critical Summary Introduction

Short: ~10 minutes Introduce glycan class / lectin family etc. http://grtc.ucsd.edu www.ncbi.nlm.nih.gov/books/NBK310274/ Essentials book will be rotating: Speaker will get book in the preceding journal club meeting (i.e. 7 days before yours)

Common Classes of Animal Glycans Symbol Nomenclature for Glycans (SNFG) Chapter 1, Figure 6. Essentials of Glycobiology, Third Edition Synthesis of dolichol-P-P-GlcNAc2Man9Glc3 Buy the Book Chapter 9, Figure 3. Essentials of Glycobiology, Third Edition

Different Groups of C-Type Lectins and Their Domain Structures Buy the Book Chapter 34, Figure 3. Essentials of Glycobiology, Third Edition Introduction Introduce glycan class / lectin family etc.

Background on context (disease, tissue, organism, etc.) What is known? What remains unknown? What system was selected to answer these questions?

What is the overall hypothesis? What are the Specific Aims? https://accessmedicine.mhmedical.com/book.aspx?bookID=2129 Make sure that everyone is on the same page, dont assume ! Critical Discussion: Methods Present the aims and/or central hypothesis

(this gets everybody on the same page) Present general methods first (those important to understand the entire article) Present specific methods together with Results (if they are only relevant to explain an individual figure or table) Materials and Methods are very important!

Critical Discussion: Results For each Figure or Table Pose the question behind the experiment. Why did the authors do the experiment? What did they hope to learn or show?

Whats the hypothesis? What were the controls and are they appropriate? If a Figure or Table leads to a clear conclusion, state it at the bottom of the slide Is lipid Uptake in Adipose Tissue Disrupted?

ANGPTL3 is essential for redirecting lipids from oxidative to storage tissue Figure Quality Figure Quality Figure Presentation R925A mutant leads to loss of b-unit

Conclusions Summarize major experimental findings, the authors conclusions, your assessment of their conclusions Indicate strength and weaknesses Indicate what questions remain unanswered

and what you think should be done next Zoom out: What are the broader implications? Common, but avoidable mistakes Article: Choosing too long a paper

Choosing a poor paper Scientific: Inadequate Introduction

Failure to provide rationale for experiments Poor description of experimental results Communication: Incorrect pace

Communicate Impress Not practicing your presentation When you are not the one presenting

(Majority of the time!) Ask questions Actively participate Read the paper Help the presenter by filling out and submitting the Feedback Forms Help the faculty by filling out and submitting the course evaluation forms Sign up!

Enrolled graduate students in beginning of the quarter http://grtc.ucsd.edu

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