Searching Medline Helen Rowlandson Principal Medicines Information Pharmacist
Searching Medline Helen Rowlandson Principal Medicines Information Pharmacist London Medicines Information (Northwick Park) London Jan 2008 course - participants responses 21 questionnaires returned More than half have had formal training (during pre-reg, at university, during diploma/
certificate, or by NHS library service) Informal training in-house in MI service Most participants use Dialog and a few use Ovid Of the Dialog users most use Advanced search option Main issues/problems Searches produce too many hits - how do you narrow your search down?
Searches produce irrelevant hits how to you find relevant hits for your topic? Searches produce no hits why is this? Finding/deciding which are the relevant search terms to use use of the MeSH browser/ MESH descriptors/MESH
headings/thesaurus What to do if a drug name isnt a MESH heading Using search terms across both Embase and Medline Use of explode function, major descriptors and subheadings
Session aims To understand the concepts of a basic search strategy in Medline To describe the MeSH thesaurus in detail so that you will be able to apply MeSH to use Medline efficiently
To carry out advanced Medline searches Plan Searching basics a refresher What is Medline? Medical Subject Headings (MeSH) NLMs MeSH browser Searching tools Dialog software the basics
Worked examples Searching basics a refresher Large databases electronic searching is essential A controlled vocabulary or a thesaurus is necessary
A means of combining terms is also required e.g. BOOLEAN operators Boolean operators A AND B A A OR B B A NOT B
A A B B What is Medline? Vast
source of medical information Medicine, Dentistry, Veterinary, Psychology Covers Clinical medicine, anatomy, pharmacology, toxicology, genetics, microbiology, pathology, environmental health, occupational medicine, psychology, biomedical technology 5,000
journals indexed, 70 countries Searching Medline Use indexing system - MeSH thesaurus Controlled vocabulary with ~23,000 descriptors Each represents a single concept Tree structure - hierarchal Constantly changing 600+ added per year
Medical Subject Headings Articles indexed by 3 tier system MeSH descriptor (MeSH heading) MeSH qualifier (MeSH subheading) Items mentioned (check tags)
Articles are indexed & then double checked by another indexer must agree MeSH Browser Open the Internet and type: http://www.nlm.nih.gov/mesh/MBrowser.html Right Now click & then click on create a shortcut
click on Navigate from tree top NLM MeSH Browser MeSH Examples Kidney Failure Depression Chronic Fatigue Syndrome PTSD Fluoxetine
NLM MeSH Browser Searching Tools Explode Includes everything below in the tree structure Focus (Major) Only includes articles where the MeSH
heading (descriptor) is the main focus of the article NLM MeSH Browser Quick questions What is the correct MeSH term to use for angina? And if you exploded this term, what term(s) would you be also including in your search?
NLM MeSH Browser Subheadings (qualifiers) Subheadings (qualifiers) refine your search What aspect of the main heading is the author writing about or discussing? Look at the definitions of the subheading e.g.:
Administration and Dosage Adverse Effects Analysis Chemistry Diagnostic use Economics History
NLM MeSH Browser Check Tags All relevant tags are attached to the article These are essentially used as limit functions
Human Child Adult Aged Male Female etc.. Type
in female and look at annotation Check tags Limits publication types If you want to search for papers that are meta analyses use the publication type limit function. Articles will then be meta-analyses If you use the MeSH heading meta-analysis as a topic from tree E the articles you will get will be about meta-analysis as a study design(methods etc..)
Look at the MESH browser for definitions Supplementary Concepts Searches for substances that are not defined in MeSH (ie dont have MeSH terms) Supplementary chemical record >30,000 substances undergoing clinical development but not all will become commercially available medicines Depending on software - search by CAS registry number and combine with text word
search using OR (not necessary in Dialog) Quick question What is directly above olanzapine in the MeSH tree? What is its CAS registry number? Medline & MeSH Recap Successful searching is finding correct
OVID DIALOG NHS MEDSCAPE Dialog software Open Internet and type: http://www.datastarweb.com/NHS/ Click Athens users click here
Right click & then click on create a shortcut Enter Athens password Dialog software Use advanced search (avoid easy
search) Medline 1951 to date or 1996 to date 3 options to search for terms: Thesaurus mapping Browse headings Enter a term Dialog NHS Dialog software Dont use punctuation e.g.
Fatigue syndrome, chronic in NLM MeSH Fatigue syndrome chronic in Dialog Subheadings Tree structure Limits Show titles Dialog NHS
Worked example 1 Are there any recent papers about SSRIs or SNRIs being used in the treatment of Huntington disease? Worked example 2 Are there any recent RCTs of the UKavailable acetylcholinesterase inhibitors (galantamine, rivastigmine, donepezil) for Lewy Body Dementia?
Worked example 3 Are there any articles which discuss using high dose vitamin supplementation to treat autistic disorders ? NB remember that your enquirers way of describing what he is asking for
may not necessarily be exactly how MeSH describes it. ANY QUESTIONS?
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