Lab and pilot plant tours - abpischools.org.uk

Lab and pilot plant tours - abpischools.org.uk

Lab and pilot plant tours Scaling up www.abpischools.org.uk Preparation of Aspirin (typical A level procedure) Pear shaped flask Bunsen burner Reflux condenser Vacuum filtration Preparation of Aspirin

(typical A level procedure) 1. Weigh out 2g of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is a fluffy irritant white solid.) 4. When it is cool, add two anti-bumping granules. 2. Add 4.0cm3 of ethanoic

anhydride. (A colourless liquid with a pungent smell.) 7. Pour into 100cm3 of cold water containing 10cm3 of dilute sulphuric acid. Stir and allow the resulting suspension to stand for 15 minutes. 3. The reaction mixture will

get slightly warm so cool it by swirling the flask under running water. 5. Heat under reflux for 30 minutes. 6. Cool the mixture. 8. Filter off the crystals that form. Dry and weigh the product.

The chemistry used to make aspirin CH3 C O O O C O C O OH

OH 2-hydroxybenzoic acid C CH3 ethanoic anhydride

OH O CH3 C O aspirin Preparation of Aspirin

(typical A level procedure) 1. Weigh out 2g of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is a fluffy irritant white solid.) How would you do this for 20kg 10,000 times the scale?

Preparation of Aspirin (typical A level procedure) 1. Weigh out 2g [20kg] of 2-hydroxybenzoic acid and place it in a pear shaped flask. (The starting material is an irritant fluffy

white solid.) Preparation of Aspirin (typical A level procedure) 2. Add 4.0cm [40 litres] of ethanoic anhydride. (A colourless liquid with a pungent smell). 3 Temperature

probe Preparation of Aspirin (typical A level procedure) 2. Add 4.0cm3 [40 litres] of ethanoic anhydride. (A colourless liquid with a pungent smell). Preparation of Aspirin (typical A level procedure)

3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water. Preparation of Aspirin (typical A level procedure) 3. The reaction mixture will get slightly warm so cool it by swirling the

flask under running water. Preparation of Aspirin (typical A level procedure) 3. The reaction mixture will get slightly warm so cool it by swirling the flask under running water.

Preparation of Aspirin (typical A level procedure) 4. When it is cool, add two anti-bumping granules. 5. Heat under reflux for 30 minutes. Heat under reflux for 30 minutes 140 120

C 100 80 60 40 20 30 60 90 120

Time in minutes 150 180 Preparation of Aspirin (typical A level procedure) 5. Heat under reflux for 30 minutes.

The maximum transfer of heat from the fluid in the jacket to the reaction mixture is 2 per minute Condenser Heat under reflux for 30 minutes 140 120

C 100 80 60 40 20 30 60 90 120

Time in minutes 150 180 Preparation of Aspirin (typical A level procedure) 6. Cool the mixture. 7. Pour into 100cm3 [1000 litres] of cold water

containing 10cm3 [100 litres] of dilute sulphuric acid. Stir and allow the resulting suspension to stand for 15 minutes. 8. Filter off the crystals that form. Dry and weigh the product. Condenser Preparation of Aspirin

(typical A level procedure) 8. Filter off the crystals that form. Dry and weigh the product. Filter off the crystals that form Dry and weigh the product

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