Ankylosing Spondylitis

Ankylosing Spondylitis

Ankylosing Spondylitis Expanded Concept of AxSpA

End-Stage Ankylosing Spondylitis

Skeletal Manifestations of AS Multisystem Manifestations of AS

Pathogenesis of AxSpA

Pathogenesis of AxSpA (cont) How Does HLA-B27 Predispose to

AS? Interaction of Microbiome & Genes

in AS Pathogenesis

How Does Dysregulation of the Gut Microbiome Lead to AxSpA Pathogenesis?

Mechanical Stress Is a Key Trigger for Enthesitis in AS & PsA

Mechanical Stress Leads to Activation of MAPK and p38 Kinases & Release

of IL-23 and IL-17 Enthesitis Precedes Development of

Spondyloarthritis Mechanical Trauma at Entheses

In a Genetically Primed Host, Mechanical Trauma at Entheses Leads to Innate Immune System

Activation & Inflammation Inflammation and Bone Erosion

Precedes New Bone Growth/Syndesmophyte Formation

Simultaneous Bone Resorption and Bone Formation at Distinct Sites Leads to Vertebral Fractures & Syndesmophyte Formation

Role of IL-17 Signaling

Effects of IL-23 and IL-17 on Osteoclasts and Osteoblasts

IL-23/IL-17 Inhibitors in Spondyloarthritis

Phase III Trials in AS JAK-STAT Cascade

2019 ACR-SAA-SPARTAN Treatment Guidelines for AxSpA

2019 ACR-SAA-SPARTAN Treatment Guidelines for AxSpA (cont)

2019 ACR-SAA-SPARTAN Treatment Guidelines for AxSpA (cont)

Concluding Remarks

Abbreviations Abbreviations (cont)

Abbreviations (cont)

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