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The Measurable Difference LIFEPAK NANO TECHNICAL OVERVIEWLIFEPAK NANO AND ITS COMPOSITIONWhat is lifepak nano?Lifepak nano is a nutritional anti-aging program formulated to nourish and protect cells, tissues, and organs inthe body with the specific purpose to guard against the ravages of aging. Lifepak nano offers the highestbioavailability with a first-ever nanotechnology process and advanced levels of key anti-aging nutrients in acomprehensive formula.*What makes lifepak nano unique?Lifepak nano is the most scientifically balanced anti-aging supplement for adults with three scientificinnovations: 1. superior bioavailability (via nanotechnology and liponutrients), 2. broad range cell and bodyprotection with more than 60 antioxidants, and 3. key ingredient advances for heart and cell health benefitsincluding resveratrol polyphenols and a new vitamin E blend.What are the health benefits of lifepak nano?Lifepak nano helps protect your health today and throughout your lifespan with superior benefits as an antiaging program. This proprietary formula protects DNA and cells, nourishes and protects the brain, bolsters theimmune system, supports cardiovascular health,, helps regulate blood sugar metabolism, protects eye health,helps build strong bones, promotes joint function and mobility, helps maintain healthy skin tone and elasticity,helps protect against the affects sun radiation, and other anti-aging benefits.*What is the recommended adult use?Take two twin sachet packets daily. Take the contents of one (1) lifepak nano twin sachet (5 capsules and 2softgels) with eight (8) ounces of liquid with your morning and evening meals.How do lifepak nano’s nano-nutrients work?Fat-soluble nutrients, like carotenoids and CoQ10, tend to cling together in the digestive tract, making themdifficult to absorb. To enhance absorbability, individual molecules are separated using nano encapsulation. Thisprocess prevents molecules from clinging together so they are individually dispersed and more available for easyabsorption. This superior bioavailability with new patent-pending CR-6 LipoNutrients is a first-ever formula todeliver Nano CoQ10 and nano-carotenoids along with other nutrients for maximum anti-aging benefit. And inthe case of coenzyme Q-10, this process of nano-encapsulation increases bioavailability by 5-10 times.What does CR-6 LipoNutrients stand for?Each serving of lifepak nano is delivered in a convenient twin sachet packet; one side contains five dry capsules,and the other side contains two CR-6 softgel capsules. The meaning of the name CR-6 stands for the sixcarotenoids (CR carotenoid) present in the softgel capsule. In addition to the six carotenoids, Vitamins A and Eare delivered along with essential omega-3 ’s (equivalent in potency to a serving of MarineOmega). The nameCR-6 LipoNutrients refers to all the contents of the softgel, all of which are fat-soluble nutrients; and all ofwhich are enhanced through pre-fat-dissolved delivery, or enhanced with nanotechnology.Who should take lifepak nano?Lifepak nano is intended for adults (ages 18 and up) who are looking for the most advanced and comprehensive*These statements have not been evaluated by the Food and Drug Administration. This product is notintended to diagnose, treat, cure, or prevent any disease. 2005 Pharmanex, LLCPrepared by G. Cheney (9/15/05)Draft 1Page 1

The Measurable Difference dietary health & wellness supplement. Lifepak nano is ideal for individuals who were previously taking eitherLifePak regular, LifePak Prime, or LifePak Women, in conjunction with MarineOmega. Due tolifepak nano ’s unique delivery of certain antioxidant, it is also ideal for individuals who feel they are geneticallypredisposed to poor absorption of carotenoids. Also, persons prone to supplement-induced nausea may find thatlifepak nano ’s sources of minerals are better tolerated.Will lifepak nano help raise my Skin Carotenoid Score?Carotenoids play a crucial role in supporting the entire antioxidant network, yet as fat soluble nutrients they arepoorly absorbed, and a small percentage of the population is extremely challenged at absorbing these importantnutrients (individuals who experience only slight increases in their SCS are known as non-responders due totheir abnormally low ability to absorb carotenoids). Lifepak nano includes nano-carotenoids to improveabsorption of these hard-to-absorb antioxidants. Improved absorption has been shown to increase SkinCarotenoid Scores.Do I still need to take MarineOmega if I take lifepak nano?Previous to the introduction of lifepak nano, all LifePak family products were recommended to be taken withMarineOmega. Each serving of lifepak nano delivers the same levels of EPA and DHA as found in a serving ofMarineOmega. If you continue taking any LifePak family product other than lifepak nano, it is stillrecommended that you take MarineOmega.Why is it important to take lifepak nano twice a day?Lifepak nano is a comprehensive supplement that contains a potent blend of essential micro- and macronutrients, as well as semi-essential nutrients shown to be generally beneficial to long-term health and well-being.It should be taken twice daily to provide your body with optimal saturation and absorption of vitamins andminerals. Twice daily delivery also provides your body 24-hour antioxidant protection of water solubleantioxidants that are flushed out of the body throughout the day.What are the 60 antioxidants in lifepak nano?All-trans-beta-carotene,11-cis-beta-carotene, 13-cis-beta-carotne, vitamin A, buffered vitamin C, all 8 forms ofnatural vitamin E (d-alpha-tocopherol, d-beta-tocopherol, d-gamma-tocopherol, d-delta-tocopherol, d-alphatocotrienol, d-beta-tocotrienol, d-gamma-tocotrienol, d-delta-tocotrienol), selenium, copper, zinc, manganese,all-trans-lycopene, all-trans-alpha-carotene, cis-lycopene, all-trans-lutein, all-trans-astaxanthin, 9-cis astaxanthin,13-cis-astaxanthin, all-trans-zeaxanthin, 9 green tea catechins and glycosides [( )-catechin (C),epicatechin (EC),epigallocatechin (EGC), epicatechin gallate (ECg), epigallocatechin gallate (EGCg), DL-Catechin (DL-C),Gallocatechin gallate (GCG),kaempferol glycoside, myricetin glycoside], 20 grape seed polyphenols(epicatechin gallate, catechin dimer, catechin dimer gallate, catechin trimer, catechin dimmer digallate, catechintrimer gallate, catechin tetramer, catechin tetramer gallate, catechin pentamer, catechin trimer digallate, catechintetramer digallate, catechin pentamer gallate, catechin hexamer, catechin pentamer digallate, catechin tetramertrigallate, catechin hexamer gallate, catechin pentamer trigallate, catechin hexamer digallate, catechin heptamer,and catechin heptamer gallate), quercetin, naringenin, hesperidin, 4 resveratrol polyphenols (trans-resveratrol,cis-resveratrol, trans-piceid, cis-piceid), novel krill flavonoid (not yet named), alpha-lipoic acid, N-acetyl-Lcysteine, coenzyme Q10.What is the difference between lifepak nano, LifePak , LifePak Prime, LifePak Women, and LifePak Prenatal?Lifepak nano has been formulated to meet the nutritional needs of all adults, ages 18-108 years (with theexception of pregnant women). Lifepak nano delivers the benefits of LifePak , LifePak Prime, and LifePak Women but with the exciting addition of nanotechnology and CR-6 LipoNutrients. CR-6 LipoNutrient softgels*These statements have not been evaluated by the Food and Drug Administration. This product is notintended to diagnose, treat, cure, or prevent any disease. 2005 Pharmanex, LLCPrepared by G. Cheney (9/15/05)Draft 1Page 2

The Measurable Difference offer enhanced absorption for nutrients known to be poorly absorbed. Also, the CR-6 LipoNutrient softgelscontain ultra-pure fish oils in amounts equivalent to a full serving of MarineOmega. A few ingredients that areavailable in LifePak Prime (such as ginkgo and glucosamine), and Lifepak Women (such as evening primroseoil and cranberry) are not offered in lifepak nano, however most of the targeted benefits of these ingredients areprovided through ingredients unique to lifepak nano; those that are not can be achieved through separatePharmanex products like Estera Cranberry.Why should I take lifepak nano instead of the combination of LifePak and MarineOmega ?Delivering the combined benefits of LifePak and MarineOmega is only the first step of understanding Lifepak nano. Lifepak nano employs nanotechnology for enhanced absorption of nutrients known to be poorly absorbed.The nanotechnology process prevents molecules from clinging together so they are more available for easyabsorption. This superior bioavailability with new patent-pending CR-6 LipoNutrients is a first-ever formula todeliver Nano CoQ10 and nano-carotenoids along with other nutrients for maximum anti-aging benefit.Does lifepak nano conform to the 6S Quality Process?The combination of quality ingredients, qualified manufacturers, certified independent laboratory verification,and a continuous drive to supply leading-edge products ensures our representatives and consumers the highestquality products available in the industry. Lifepak nano is guaranteed to contain no added sugar, salt, wheat,dairy products, artificial preservatives or colors. The vitamins and minerals used in Pharmanex products meet therequirements and guidelines established by the United States Pharmacopoeia (USP) and/or Food ChemicalsCodex (FCC) where applicable. Every batch of lifepak nano meets the USP XXV requirements for capsuledisintegration. All ingredients are tested for purity, and where applicable, ingredients are certified pure bymicrobial testing, such as tests for Salmonella, E. coli, other coliforms, Staphylococcus aureus, total plate counts,yeasts, molds, and pesticide residues. Our manufacturers go through a detailed selection and certification processto assure their compliance with Good Manufacturing Practice (GMP) standards set by the Food and DrugAdministration (FDA).What is the best way to open the twin sachets?Lifepak nano comes in a convenient twin sachet packet, with a compartment for the dry capsules, and acompartment for the CR-6 softgels. The compartments can be opened separately, or for greater convenience: foldthe twin sachet along the seal that separates the compartments. Once you have folded the twin sachet, the packetwill be “doubled-up ” allowing you to tear along the serrated edge of both ends of the packet. In this way you canopen up both sachets with one tear.NANOTECHNOLOGYWhat is nanotechnology?As applicable to nutrition, nanotechnology is the manipulation of nutrients at the molecular level to enhance theirbenefits to the body. A nanometer represents 1 billionth of a meter, and provides a useful unit for measuringultra-small molecules. The application of nanotechnology employed by Pharmanex is a mono-molecularencapsulation where single molecules of important nutrients are embedded into single nanocapsule molecules.Since every single molecule of each nanoized-nutrient is wrapped in its own individual nanocapsule there iscomplete molecular dispersion of the fat-soluble nutrients. With complete molecular dispersion, the surface areaof the nutrient is maximized as is its contact with the lining of the gastrointestinal tract. The nutrient is absorbedthrough the gut, and the encapsulating-molecule is left behind where it is degraded by digestive enzymes.How does lifepak nano improve delivery of certain fat-soluble vitamins?*These statements have not been evaluated by the Food and Drug Administration. This product is notintended to diagnose, treat, cure, or prevent any disease. 2005 Pharmanex, LLCPrepared by G. Cheney (9/15/05)Draft 1Page 3

The Measurable Difference While some nutrients in lifepak nano have been enhanced through nanotechnology, yet others have beenenhanced through their delivery in LipoNutrient form. Other fat soluble vitamins have been included as part ofthe CR-6 softgel capsules. Because these fat soluble nutrients are delivered in a matrix of essential omega-3 fattyacids, they are pre-dissolved for superior bioavailability.What is unique about the nano-carotenoid blend?Carotenoids play a crucial role in supporting the entire antioxidant network, yet they are poorly absorbed.Because carotenoids act as a first line of defense against external free-radicals they receive free radical hits first,thus sparing other antioxidant in the network. Lifepak nano includes nano-carotenoids to improve absorption ofthese hard-to-absorb antioxidants. With greater absorption of carotenoids (made possible by nanotechnology)other network antioxidants are reserved to protect cell structures against internally produced free-radicals.Which nutrients are in nano-form in lifepak nano?Nanotechnology is only one example of methods Pharmanex has employed to improve absorption of lifepak nano ’s nutrients. The specific nutrients that have been enhanced with nanotechnology include those known to bepoorly absorbed in the digestive tract, including beta-carotene, alpha carotene, astaxanthin, zeaxanthin, lycopeneand CoQ10. These nutrients have been manipulated to enhance their bioavailability without altering theirfunction as nutrients.Why aren’t all the ingredients in lifepak nano in nano-form?Pharmanex scientists worked to identify molecules which are poorly absorbed and applied nanotechnologyspecifically to these nutrients. Most water soluble nutrients are easily absorbed, while the hydrophobic propertiesof fat soluble nutrients (such as carotenoids) make them difficult to absorb. Beyond nanotechnology, lifepak nano employs other methods to enhance bioavailability, including liponutrients, chelated minerals and bufferedvitamin C. Each of these nutrient forms were selected for their superior absorption properties.How does lifepak nano meet or exceed the requirements for a bona fide “nanotechnology” productLifepak nano meets or exceeds federal requirements of a nanotechnology product. This ter